反应详情

2,3-Difluorobenzoic acid (5.0 g, 31.6 mmol) was dissolved in trifluoromethanesulfonic acid (25 ml) and N-iodosuccinimide (8.55 g, 38.0 mmol) was cast by portions under an argon stream at 0° C. After stirring at room temperature for 3 hr, the reaction mixture was poured into sodium sulfite in ice water and stirred. The precipitated solid was collected by filtration, washed with water, and vacuum dried to give the object product (7.5 g, yield 84%) as a pale-pink solid.

1. customat 0° C
2. stirringstirred
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with water, and vacuum
5. customdried