反应详情

温度

210 °C

5-Nitro-2-trifluoromethylanisole (10.7 g, 48.5 mmol) and pyridine hydrochloride (44.9 g, 388 mmol) were combined in a round-bottom flask and heated at 210° C. for 2 h. The reaction was cooled to RT and dissolved into 6 N HCl and EtOAc. The layers were separated, and the organic layer was washed 4× with 2 N HCl and once with brine, dried over Na2SO4, filtered, and concentrated in vacuo, to yield the title compound as a dark red solid.

1. temperatureThe reaction was cooled to RT
2. customThe layers were separated
3. washthe organic layer was washed 4× with 2 N HCl
4. dry with materialonce with brine, dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo