Oxalyl chloride → 2,2-diphenylpropanoyl Chloride

HRID 49171Notes

Reaction equation

HRID 49171 reaction equation
C(Cl)(=O)C([Cl:4])=O.[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14](O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C)C=O.ClCCl>[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14]([Cl:4])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 796762,2-Diphenylpropionic acid

Product 1

HCID 114479422,2-diphenylpropanoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

52.08 g (0.33 mol) of oxalyl chloride are slowly added dropwise to a suspension of 25.0 g (0.11 mol) of 2,2-diphenylpropionic acid, 100 ml of dichloromethane and 4 drops of dimethylformamide at 20° C. The mixture is stirred for 1 h at 20° C. and 0.5 h at 50° C. The solvent is distilled off and the residue remaining is used in the next step without any further purification.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue remaining is used in the next step without any further purification

Sources & evidence

ORD record
ord-8b7f1a0bba1c45d095704088e79bca10
Source dataset
uspto-grants-2004_03
Patent number
US06706726B2

Reaction notes

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