Hydrochloric Acid → HCID 10126937, compound

HRID 491783Notes

Reaction equation

HRID 491783 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([NH:17][C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][C:19]=2[C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][N:31]=2)=[O:28])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([NH:17][C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][C:19]=2[C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][N:31]=2)=[O:28])=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23062671HCID 23062671, compound

Product 1

HCID 10126937HCID 10126937, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

3-[2-(1-t-Butoxycarbonylpiperidin-4-yl)acetylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (2.34 g) obtained in Example 212 is suspended in ethyl acetate (30 ml), and thereto is added 2.6N hydrogen chloride in ethyl acetate (30 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is concentrated under reduced pressure, and to the resulting residue are added chloroform and an aqueous sodium hydrogen carbonate solution. The precipitates are collected by filtration to give the title compound (1.47 g).

Workup

  1. concentrationThe reaction solution is concentrated under reduced pressure
  2. additionto the resulting residue are added chloroform
  3. filtrationThe precipitates are collected by filtration

Sources & evidence

ORD record
ord-3caa32c58db54db9a6b33a232b984c30
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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