反应详情

Trans-5-methoxycarbonyl-3-[4-(methylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide hydrochloride (1.50 g) obtained in Example 218 is suspended in dichloromethane (80 ml), and thereto are added acetyl chloride (307 μl) and triethylamine (1.60 ml) under ice-cooling. The mixture is warmed to room temperature, and stirred for 2 hours. To the reaction solution is poured a saturated aqueous sodium hydrogen carbonate solution, and the mixture is extracted with chloroform, washed with water and a saturated brine, and dried over sodium sulfate. The solvent is evaporated under reduced pressure, and the resulting residue is purified by NH-silica gel column chromatography (eluent: chloroform) to give the title compound (1.51 g).

1. temperaturecooling
2. extractionthe mixture is extracted with chloroform
3. washwashed with water
4. dry with materiala saturated brine, and dried over sodium sulfate
5. customThe solvent is evaporated under reduced pressure
6. customthe resulting residue is purified by NH-silica gel column chromatography (eluent: chloroform)