反应详情

温度

110 °C

A solution of 2-chloro-4-methyl-5-nitropyridine (10 g, 0.058 mol), in DMF (100 mL) was treated with phenol (6.6 g, 0.07 mol) and potassium carbonate (9.6 g, 0.07 mol) and the reaction mixture was stirred at 110° C. for 4 hr and then cooled. To the reaction mixture was then added water. The reaction mixture was extracted into EtOAc, dried and concentrated to a syrup, which was purified via column chromatography (4:2:0.5; CHCl3:hexanes:EtOAc, v/v) to yield 4-methyl-5-nitro-2-phenoxy-pyridine as a light yellow solid.

1. temperaturecooled
2. extractionThe reaction mixture was extracted into EtOAc
3. customdried
4. concentrationconcentrated to a syrup, which
5. customwas purified via column chromatography (4:2:0.5; CHCl3:hexanes:EtOAc, v/v)