1-Bromo-3-chloropropane → 1-(3-Chloropropyl)-4-(trifluoromethyl)piperidin-4-ol

HRID 492030Notes

Reaction equation

HRID 492030 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1([OH:9])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[CH2:13][CH2:14][CH2:15][Cl:16]>>[Cl:16][CH2:15][CH2:14][CH2:13][N:6]1[CH2:5][CH2:4][C:3]([C:2]([F:1])([F:10])[F:11])([OH:9])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 179513214-(Trifluoromethyl)-4-piperidinol

Product 1

HCID 184498311-(3-Chloropropyl)-4-(trifluoromethyl)piperidin-4-ol

Procedure

A solution of 4-(trifluoromethyl)piperidin-4-ol and 1-bromo-3-chloropropane are reacted using the procedure for Example OO to afford 1-(3-chloropropyl)-4-(trifluoromethyl)piperidin-4-ol.

Sources & evidence

ORD record
ord-d534f5a4cf2444f8a17ddd43d6538c31
Source dataset
uspto-grants-2009_05
Patent number
US07531566B2

Reaction notes

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