Methylamine → HCID 57678987, compound

HRID 492096Notes

Reaction equation

HRID 492096 reaction equation
C(O[C:4](=[O:28])[CH2:5][NH:6][CH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)(=[O:21])=[O:20])=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)C.[CH3:29][NH2:30]>CO>[C:22]1([S:19]([NH:18][C:14]2[CH:13]=[C:12]3[C:17](=[CH:16][CH:15]=2)[C:8]([CH2:7][NH:6][CH2:5][C:4]([NH:30][CH3:29])=[O:28])=[CH:9][CH:10]=[CH:11]3)(=[O:21])=[O:20])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 57679000HCID 57679000, compound

Product 1

HCID 57678987HCID 57678987, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-amino]-acetic acid ethyl ester is added to methylamine in methanol, and the solution is stirred at room temperature, then concentrated under reduced pressure. The oil is dissolved in ethanol and 1N HCl in diethyl ether is added to precipitate 2-[(6-benzenesulfonyl-naphthalen-1-ylmethyl)-amino]-N-methyl-acetamide as a hydrochloride salt.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe oil is dissolved in ethanol
  3. addition1N HCl in diethyl ether is added
  4. customto precipitate 2-[(6-benzenesulfonyl-naphthalen-1-ylmethyl)-amino]-N-methyl-acetamide as a hydrochloride salt

Sources & evidence

ORD record
ord-a9348aec42f1420894b75dfc24901c10
Source dataset
uspto-grants-2009_05
Patent number
US07531577B2

Reaction notes

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