反应详情

温度

55 °C

Twenty grams of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid and 14.2 g (2.1 eq) of 2-methyl piperazine were suspended in DMSO (400 mL) under a blanket of nitrogen. The mixture was heated to 55° C. during 24 hours. Subsequently, the mixture was heated to 70° C. and half of the amount of DMSO was distilled-off at reduced pressure (1-5 mm Hg). At the end of the distillation, dimethylcarbonate (200 mL) was added, the reaction mixture was cooled to 5° C. and held at this temperature overnight. The mixture was then filtered under vacuum. The compound was then dried under vacuum to obtain 20.22 g after assay (76% yield) of gatifloxacin.

1. temperatureSubsequently, the mixture was heated to 70° C.
2. distillationAt the end of the distillation, dimethylcarbonate (200 mL)
3. additionwas added
4. temperaturethe reaction mixture was cooled to 5° C.
5. customheld at this temperature overnight
6. filtrationThe mixture was then filtered under vacuum
7. customThe compound was then dried under vacuum