反应详情

2 g of 2-[[(3,5-dimethyl-4-methoxy-2-pyridinyl)methyl]thio]-5-methoxy-1H-benzimidazole was suspended in 36 ml of methanol at room temperature, to which 1.88 g of 45% NaOH in 14 ml water was added while stirring. 0.09 g of Na2WO4·2H2O oxidation catalyst was dissolved in 0.74 g H2O2 (50% aqueous solution), and further diluted with 10 ml. of water. The oxidant/catalyst solution was added to the reactant/base solution dropwise so that the addition was completed in about 30 minutes while stirring at room temperature. The reaction was continued for additional 10 minutes while stirring. 10 ml of 10% Na2S2O3 aqueous solution was then added, and the resulting mixture was subjected to a reduced pressure to remove methanol therefrom. Finally, a precipitate was formed after adding a diluted acetic acid aqueous solution to a pH value of about 8, which was filtered, water washed, and dried in vacuo to obtain Omeprazole with a yield of about 88% (LC purity>95%).

1. additionwas added
2. additionfurther diluted with 10 ml
3. additionThe oxidant/catalyst solution was added to the reactant/base solution dropwise so that the addition
4. stirringwhile stirring at room temperature
5. waitThe reaction was continued for additional 10 minutes
6. stirringwhile stirring
7. customto remove methanol
8. customFinally, a precipitate was formed
9. filtrationwas filtered
10. washwater washed
11. customdried in vacuo