反应详情

0.5 g of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole was suspended in 7 ml of ethanol at room temperature. 0.025 g of Na2WO4·2H2O oxidation catalyst was dissolved in 0.141 g H2O2 (35% aqueous solution), and further diluted with 2 ml of water. The oxidant/catalyst solution was added to the reactant suspension dropwise so that the addition was completed in about 30 minutes while stirring at room temperature. The reaction was continued for additional 8 hours while stirring. 2 ml of 10% Na2S2O3 aqueous solution was then added, and the resulting mixture was subjected to a reduced pressure to remove ethanol therefrom. Finally, a precipitate was formed after adding a diluted acetic acid aqueous solution to a pH value of about 8, which was filtered, water washed, and dried in vacuo to obtain Lansoprazole with a yield of about 63% (LC purity>80%).

1. additionThe oxidant/catalyst solution was added to the reactant suspension dropwise so that the addition
2. waitThe reaction was continued for additional 8 hours
3. stirringwhile stirring
4. customto remove ethanol
5. customFinally, a precipitate was formed
6. filtrationwas filtered
7. washwater washed
8. customdried in vacuo