反应详情

To a solution of compound 20 (2.0 g, 8.4 mmol) in DMF (28 mL) at room temperature was added sodium hydride (235 mg, 8.8 mmol) and ethyl bromoacetate (1.03 mL, 9.2 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture is poured onto water and extracted with ethyl acetate (3×100 mL). The combined ethyl acetate extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to provide 2 g of 21 as a clear oil (2.73 g theoretical, 73% yield)

1. customthe resulting reaction mixture
2. additionThe reaction mixture is poured onto water
3. extractionextracted with ethyl acetate (3×100 mL)
4. dry with materialThe combined ethyl acetate extracts were dried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo