反应详情

To a solution of compound 21 (2.0 g, 6.15 mmol) in methanol (20 mL) and water (5 mL) was added potassium carbonate (1.3 g, 9.4 mmol) and the resulting reaction mixture was allowed to stir at reflux for 2 hours. The reaction mixture is poured onto 1N HCl and extracted with dichloromethane (3×100 mL) and the combined dichloromethane extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to provide 1.7 g of 22 as a white solid (1.83 g theoretical, 93% yield).

1. customthe resulting reaction mixture
2. temperatureat reflux for 2 hours
3. extractionextracted with dichloromethane (3×100 mL)
4. dry with materialthe combined dichloromethane extracts were dried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo