反应详情

At 0° C., lithiumaluminium hydride (1.7 g) was added to a THF solution (58 mL) of 6-amino-nicotinic acid (2.0 g), and stirred overnight at room temperature. Sodium sulfate 10 hydrate was added to the reaction liquid at 0° C. to stop the reaction, and this was dried with anhydrous sodium sulfate. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure to obtain (6-amino-3-pyridinyl)methanol (1.7 g) as a brown solid.

1. customthe reaction
2. dry with materialthis was dried with anhydrous sodium sulfate
3. filtrationThe reaction mixture was filtered through Celite
4. concentrationthe filtrate was concentrated under reduced pressure