Pentylamine → HCID 12071574, compound

HRID 492286Notes

Reaction equation

HRID 492286 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH2:3][CH2:4][CH3:5].[C:7]1([C:13]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:14]2[C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[CH:30]=[CH:29][C:28]([CH2:31]Br)=[CH:27][CH:26]=3)=[N:17][N:16]=[N:15]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:45][C:46]1[CH:51]=[C:50]([CH3:52])[CH:49]=[C:48]([CH3:53])[C:47]=1[NH:54][C:55](=O)[O:56]C1C=CC=CC=1>C(N(CC)CC)C>[CH2:1]([N:6]([CH2:31][C:28]1[CH:29]=[CH:30][C:25]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[C:18]2[N:14]([C:13]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:15]=[N:16][N:17]=2)=[CH:26][CH:27]=1)[C:55](=[O:56])[NH:54][C:47]1[C:48]([CH3:53])=[CH:49][C:50]([CH3:52])=[CH:51][C:46]=1[CH3:45])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 8060PentylamineHCID 691608phenyl 2,4,6-trimethylphenylcarbamateHCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole

Product 1

HCID 12071574HCID 12071574, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Using n-pentylamine (304.2 mg), triethylamine (442.2 mg), [[2′-(N-(triphenylmethyl)tetrazol-5-yl]-1,1′-biphenyl-4-yl]methyl] bromide (400 mg) and phenyl 2,4,6-trimethylphenylcarbamate (233.8 mg), N′-pentyl-N-(2,4,6-trimethylphenyl)-N′-[[2′-[N-(triphenylmethyl)tetrazol-5-yl]-1,1′-biphenyl-4-yl]methyl]urea (113 mg) was obtained by a similar procedure as in Example 1. Yield: 22%.

Sources & evidence

ORD record
ord-d6a134d493ce4578ab94455a2350b8a8
Source dataset
uspto-grants-2009_05
Patent number
US07531576B2

Reaction notes

Loading…