Hydrogen Peroxide → 3,5-Difluoro-4-(4-formyl-phenoxy)benzamide

HRID 492560Notes

Reaction equation

HRID 492560 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:19])[C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]#[N:6].OO.C(=O)([O-])[O-:23].[K+].[K+]>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:19])[C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[O:18])=[CH:13][CH:12]=1)[C:5]([NH2:6])=[O:23]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 597299063,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

Product 1

HCID 597301093,5-Difluoro-4-(4-formyl-phenoxy)benzamideYield 99%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Hydrolysis of the compound of step 1 using hydrogen peroxide and potassium carbonate in DMSO as described previously afford the above compound in 99% yield.

Workup

  1. customas described previously afford the above compound in 99% yield

Sources & evidence

ORD record
ord-4c8b319abb4543c0955481b37768507d
Source dataset
uspto-grants-2009_05
Patent number
US07531557B2

Reaction notes

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