反应详情

To a solution of 1-(4-pyridyl)-2-imidazolidinone (100 mg, 0.61 mmol) and 3-[(6-bromohexyl)oxy]-5-chloropyridine (269 mg, 0.92 mmol) in DMF (5 mL) was added sodium hydride (39 mg, 1.23 mmol, 75% in mineral oil) in an ice bath. The mixture was stirred at room temperature overnight. After removing the solvent under reduced pressure, the crude residue was purified by column chromatography eluted with 15% methanol in ethyl acetate to afford the product (i.e., Compound 11) as a light yellow solid (0.17 g, 75%).

1. customAfter removing the solvent under reduced pressure
2. customthe crude residue was purified by column chromatography
3. washeluted with 15% methanol in ethyl acetate