反应详情

1-[4-(4-Aminophenoxy)pyridin-2-yl]-3,3dimethylurea (30 mg) was dissolved in N,N-dimethylformamide (1 ml) under a nitrogen atmosphere, and then N-(4-fluorophenyl)malonic acid (65.1 mg), triethylamine (0.046 ml) and (1H-1,2,3-benzotriazol-1-yloxy)[tri(dimethylamino)]phosphonium hexafluorophosphate (146 mg) were added thereto at 50° C., followed by stirring at the same temperature for 1.5 hr. The reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and a 1 N aqueous solution of sodium hydroxide. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, a saturated aqueous solution of ammonium chloride, water and brine in this order, and dried over anhydrous sodium sulfate. The solvent was evaporated to give a residue, which was then purified by silica gel column chromatography (FUJI Silysia NH, eluent; hexane:ethyl acetate=1:5 to 1:8). Fractions containing the target compound were concentrated to give a residue, to which diethyl ether (2 ml)-hexane (2 ml) was added to suspend. The solid was filtered off and dried under aeration to provide the titled compound (43.4 mg, 87.4%) as a white solid.

1. customat 50° C.
2. custompartitioned between ethyl acetate
3. washThe organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate
4. dry with materiala saturated aqueous solution of ammonium chloride, water and brine in this order, and dried over anhydrous sodium sulfate
5. customThe solvent was evaporated
6. customto give a residue, which
7. customwas then purified by silica gel column chromatography (FUJI Silysia NH, eluent; hexane:ethyl acetate=1:5 to 1:8)
8. additionFractions containing the target compound
9. concentrationwere concentrated
10. customto give a residue
11. filtrationThe solid was filtered off
12. customdried under aeration