反应详情

Resorcinol (10.0 g, 91 mmol) and isobutyric acid (8.00 g, 1 eq.) were treated with BF3-etherate (68 mL, 6 eq.) and heated for 1.5 h to 90° C. After cooling the reaction mixture was carefully poured onto 500 mL of 10% aq. NaOAc solution, twofold extracted with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness to leave 18.5 g of the title compound as light brown oil.

1. temperatureheated for 1.5 h to 90° C
2. temperatureAfter cooling the reaction mixture
3. extractiontwofold extracted with AcOEt
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customevaporated to dryness