反应详情

温度

0 °C

2.2 g (6.9 mmol) of (E)-7-(5-bromo-2-thienyl)-3-ethyloct-6-en-3-ol are dissolved in 50 mL of dichloromethane. 25 mg (0.2 mmol) of 4-dimethylaminopyridine and 4.8 mL of triethylamine (34.8 mmol) are added and the reaction medium is cooled to 0° C. 3.9 mL (17.4 mmol) of triethylsilyl trifluoromethanesulphonate are added dropwise. After the addition, the reaction medium is warmed to room temperature and then treated with water and extracted with dichloromethane. After separation of the phases by settling, drying and concentration of the organic phases under reduced pressure, the residue obtained is purified by chromatography on a column of silica. A yellow oil is obtained (m=2.3 g; Y=97%).

1. additionAfter the addition
2. customthe reaction
3. temperaturemedium is warmed to room temperature
4. extractionextracted with dichloromethane
5. customAfter separation of the phases
6. customdrying
7. customconcentration of the organic phases under reduced pressure, the residue obtained
8. customis purified by chromatography on a column of silica
9. customA yellow oil is obtained (m=2.3 g; Y=97%)