反应详情

To a solution of 2,4-dimethoxytoluene (5.50 g, 36.1 mmol) in 55 mL of N-methyl-N-phenyl-formamide was added at 0° C. POCl3 (10.9 mL, 3 eq.), and the mixture was heated for 60 Min. to 80° C. After cooling, the reaction mixture was poured onto crashed ice, the precipitate filtered and washed twice with water/MeOH=8/2 to leave after drying 5.40 g of the title product as light yellow crystals.

1. customto 80° C
2. temperatureAfter cooling
3. additionthe reaction mixture was poured
4. filtrationthe precipitate filtered
5. washwashed twice with water/MeOH=8/2
6. customto leave
7. dry with materialafter drying 5.40 g of the title product as light yellow crystals