2-Methylpiperazine → HCID 22036543, compound

HRID 493268Notes

Reaction equation

HRID 493268 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:18][CH:19]1[CH2:24][NH:23][CH2:22][CH2:21][NH:20]1>>[CH3:18][CH:19]1[NH:20][CH2:21][CH2:22][N:23]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 660572-MethylpiperazineHCID 22036365HCID 22036365, compound

Product 1

HCID 22036543HCID 22036543, compound

Procedure

The title compound was prepared according to the procedure described In Example 4, Step 2, starting from 2-chloro-3-(2-phenoxyethoxy)pyrazine (150 mg, 0.54 mmol; from Example 1, Step 1) and 2-methylpiperazine (250 mg, 2.5 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out This gave 138 mg (73%) of the title product. Anal. (C17H22N4O2) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-4202fb3398f24ac6a1c51ab1e45f4360
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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