反应详情

温度

65 °C

To a stirred solution of 2-(3-hydroxyphenoxy)ethanol (7.71 g, 0.05 mol) in dry DMF (100 mL) at ˜0° C. (ice bath) was added NaH (3.90 g, 0 163 mol) in portions under N2. When the H2-evolution had ceased, a solution of 2-chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine (0.05 mol, 14.9 g; from Example 52, Step 1) in dry DMF (70 mL) was added in one portion. The mixture was stirred at 65° C. for 1.75 h. After cooling, the reaction was quenched by addition of H2O in DMF. The mixture was filtered and concentrated. in vacuo. The residue was dissolved in EtOAc, washed with 1 M KHSO4 and water, dried (Na2SO4 +Norit), and concentrated in vacuo to give the title compound as a beige sticky oil. Yield 94%. This product was used directly in the next step without further purification.

1. temperatureAfter cooling
2. customthe reaction was quenched by addition of H2O in DMF
3. filtrationThe mixture was filtered
4. concentrationconcentrated
5. dissolutionThe residue was dissolved in EtOAc
6. washwashed with 1 M KHSO4 and water
7. dry with materialdried (Na2SO4 +Norit)
8. concentrationconcentrated in vacuo