反应详情

7-Nitro-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid (6.25 g) was dissolved into DMF (50 ml), to which then potassium carbonate (11 g) and methyl iodide (4.9 ml) were added, and was stirred for 2 hours at room temperature. After the insoluble matter was filtered off and the filtrate was concentrated, ethyl acetate (500 ml) was added to the residue, which was then washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to give the intended compound 6.65 g (quantitatively) as yellow crystal.

1. filtrationAfter the insoluble matter was filtered off
2. concentrationthe filtrate was concentrated
3. additionethyl acetate (500 ml) was added to the residue, which
4. washwas then washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was distilled off