Hydrogen Bromide → HCID 67073671, compound

HRID 493414Notes

Reaction equation

HRID 493414 reaction equation
[BrH:1].[Br:2][C:3]([CH3:28])([CH3:27])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)=[O:5].BrBr>ClCCl>[Br:2][C:3]([CH3:28])([CH3:27])[C:4]([C:6]1[CH:7]=[CH:8][C:9]([S:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([C:21]3([Br:1])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[CH:15][CH:14]=2)=[CH:10][CH:11]=1)=[O:5]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 67073715HCID 67073715, compound

Product 1

HCID 67073671HCID 67073671, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A drop of 48% HBr was added to a solution of 11.95 g (26.83 mmol) of 2-bromo-1-[4-(4-cyclohexancarbonyl-phenylsulphanyl)-phenyl]-2-methyl-propan-1-one dissolved in 120 ml of dichloromethane; in 15′ 1.37 ml (26.83 mmol) of bromine dissolved in 10 ml of dichloromethane were added drop wise. After 1 h the organic phase was washed with water and with a sodium metabisulphite solution. The organic phase was separated, washed with brine, dried with sodium sulphate, filtered and evaporated under vacuum obtaining 14.07 g of a yellowish oil.

Workup

  1. additionwere added drop wise
  2. washAfter 1 h the organic phase was washed with water and with a sodium metabisulphite solution
  3. customThe organic phase was separated
  4. washwashed with brine
  5. dry with materialdried with sodium sulphate
  6. filtrationfiltered
  7. customevaporated under vacuum

Sources & evidence

ORD record
ord-df24018a53cd45bdbcf8d6237823b526
Source dataset
uspto-grants-2009_05
Patent number
US07534880B2

Reaction notes

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