Hydrochloric Acid → HCID 11632085, compound

HRID 493430Notes

Reaction equation

HRID 493430 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[N:17]=[C:16]([C:21]([OH:23])=O)[CH:15]=[CH:14]3)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl.[CH2:25]([NH2:29])[CH:26]([CH3:28])[CH3:27].C(N1C=CN=C1)(N1C=CN=C1)=O>>[CH2:25]([NH:29][C:21]([C:16]1[CH:15]=[CH:14][C:13]2[C:18](=[CH:19][CH:20]=[C:11]([O:10][CH:7]3[CH2:8][CH2:9][N:4]([CH:1]([CH3:2])[CH3:3])[CH2:5][CH2:6]3)[CH:12]=2)[N:17]=1)=[O:23])[CH:26]([CH3:28])[CH3:27]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6558IsobutylamineHCID 682631,1'-CarbonyldiimidazoleHCID 57681576HCID 57681576, compound

Product 1

HCID 11632085HCID 11632085, compound

Procedure

According to the procedure described for the synthesis of example 1, (6-(1-isopropyl-piperidin-4-yloxy)-quinoline-2-carboxylic acid isobutyl-amide was synthesized from 6-(1-isopropyl-piperidin-4-yloxy)-quinoline-2-carboxylic acid 1:1 hydrochloride, isobutylamine (commercially available) and 1,1′-carbonyl-diimidazole. MS (m/e): 370.6 (M+H).

Workup

  1. customdescribed for the synthesis of example 1

Sources & evidence

ORD record
ord-93f7eb88c12e456a91d54206dfc0fdf1
Source dataset
uspto-grants-2009_05
Patent number
US07534891B2

Reaction notes

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