反应详情

A mixture of [(3,5-dichlorophenyl)methyl]amine (100 mg), 2-bromo-1, 1bis(methyloxy)ethane (123 μL) and K2CO3 (95 mg) in anhydrous DMF (2 mL) was processed by microwave irradiation at 150° C. for 10 min (3 cycles). The mixture was allowed to cool to rt, water was added and mixture extracted three times with AcOEt, the organic phases collected, washed with brine, dried and evaporated under vacuum to give a crude which was purified by flash cromathography eluting with CH:AcOEt=9:1 to 85:15 to afford the title compound (120 mg) as a colourless oil.

1. customwas processed by microwave irradiation at 150° C. for 10 min (3 cycles)
2. extractionmixture extracted three times with AcOEt
3. customthe organic phases collected
4. washwashed with brine
5. customdried
6. customevaporated under vacuum
7. customto give a crude which
8. customwas purified by flash cromathography
9. washeluting with CH