反应详情

A mixture of 4′-hydroxy-4-nitro-biphenyl (2.00 g, 7.51 mmol), prepared in the previous step, methyl bromoacetate (853 mL, 9.02 mmol) and potassium iodide (86 mg, 0.75 mmol) in 50 mL of acetone was stirred at room temperature until the mixture became cloudy. Potassium carbonate (2.26 g, 16.4 mmol) was added and the reaction refluxed overnight. The reaction was concentrated under reduced pressure and the residue partitioned between methylene chloride and water. The organic layer was separated, washed with water, dried (Na2SO4) and the solvent removed under reduced pressure to give (4′-nitro-biphenyl-4-yloxy)-acetic acid methyl ester.

1. temperaturethe reaction refluxed overnight
2. concentrationThe reaction was concentrated under reduced pressure
3. customthe residue partitioned between methylene chloride and water
4. customThe organic layer was separated
5. washwashed with water
6. dry with materialdried (Na2SO4)
7. customthe solvent removed under reduced pressure