(3E,5E)-6-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol → HCID 86759391, compound

HRID 49367Notes

Reaction equation

HRID 49367 reaction equation
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:36]=[CH:37][C:38]=1[CH2:39][O:40][Si](C(C)(C)C)(C)C)[O:13][CH2:14][C:15]1[S:19][C:18](/[C:20](/[CH2:34][CH3:35])=[CH:21]/[CH:22]=[CH:23]/[C:24]([C:30]([F:33])([F:32])[F:31])([OH:29])[C:25]([F:28])([F:27])[F:26])=[CH:17][CH:16]=1)(C(C)(C)C)(C)C>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[OH:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:36]=[CH:37][C:38]=1[CH2:39][OH:40])[O:13][CH2:14][C:15]1[S:19][C:18](/[C:20](/[CH2:34][CH3:35])=[CH:21]/[CH:22]=[CH:23]/[C:24]([C:30]([F:33])([F:31])[F:32])([OH:29])[C:25]([F:26])([F:28])[F:27])=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 88011818(3E,5E)-6-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol

Product 1

HCID 86759391HCID 86759391, compound

Reagents, catalysts & solvents 1

HCID 74236Tetrabutylammonium BromideCatalyst

Procedure

In a manner similar to that of Example 6(l), by reaction of 200 mg of (3E,5E)-6-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol with 700 μL (0.7 mmol) of 1.0 M tetrabutylammonium bromide, the desired product is obtained in the form of white crystals (m.p.=113-114° C.; m=70 mg).

Sources & evidence

ORD record
ord-3bb37f5d8ff641d7b8a15d54ca1c6800
Source dataset
uspto-grants-2004_03
Patent number
US06706725B1

Reaction notes

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