反应详情

To a solution of 5-methyl-1H-pyrazole-3-carbaldehyde (Werner A. et al., Tetrahedron, 51, 4779 (1995): 1.1 g) in acetonitrile (20 mL), triethylamine (1.5 mL) and chlorotriphenylmethane (3.1 g) were added and mixed for 12 hours. The reaction solution was concentrated, and the residue was dissolved in chloroform. This solution was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous sodium sulfate. The solvent was distilled off, and the residue was purified with a silica gel column to give the title compound (1.9 g) as a colorless solid.

1. additionmixed for 12 hours
2. concentrationThe reaction solution was concentrated
3. dissolutionthe residue was dissolved in chloroform
4. washThis solution was washed with a saturated aqueous sodium bicarbonate solution
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent was distilled off
7. customthe residue was purified with a silica gel column