1-Ethylpiperazine → 4-[(4-Ethyl-1-piperazinyl)methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

HRID 494013Notes

Reaction equation

HRID 494013 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].[CH:9]([CH:11]1[CH2:16][CH2:15][N:14]([C:17]([OH:19])=[O:18])[CH2:13][CH2:12]1)=O>>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:11]([CH3:16])([CH3:12])[CH3:9])=[O:18])[CH2:13][CH2:12]2)[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 21994195HCID 21994195, compound

Product 1

HCID 535517464-[(4-Ethyl-1-piperazinyl)methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl esterYield 78%

Procedure

In operating analogously to preparation LXXIII, starting with N-ethylpiperazine and the t-butyl ester of 4-formyl-1-piperidinecarboxylic acid, the product sought after is obtained as a colourless oil (yield=78%).

Workup

  1. customIn operating analogously to preparation LXXIII

Sources & evidence

ORD record
ord-828ff378b40d4d1ebf37dbff17c36249
Source dataset
uspto-grants-2009_05
Patent number
US07538111B2

Reaction notes

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