反应详情

To a solution of 1-(3,4-dichloro-5-isothiazolyl)-3-(4-ethoxymethoxyphenyl)-1,3-propanedione (1.20 g) in a mixture of isopropanol (20 ml) and tetrahydrofuran (20 ml) concentrated hydrochloric acid (3.40 g) was added at room temperature and the mixture was stirred for 12 hours. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent hexane:ethyl acetate=50:50) to obtain 1-(3,4-dichloro-5-isothiazolyl)-3-(4-hydroxyphenyl)-1,3-propanedione (0.90 g). mp 224-227° C.

1. additionwas added at room temperature
2. distillationAfter distilling off the solvent under reduced pressure
3. customthe residue was purified by silica gel column chromatography (eluent hexane:ethyl acetate=50:50)