HCID 6428849, compound → 1,5-Dimethylpiperazin-2-one

HRID 494098Notes

Reaction equation

HRID 494098 reaction equation
[CH3:1][N:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[CH:4][C:3]1=[O:9]>C(OCC)(=O)C.[Pt]=O>[CH3:1][N:2]1[CH2:7][CH:6]([CH3:8])[NH:5][CH2:4][C:3]1=[O:9]

Participants

4

Reactant 1

HCID 6428849HCID 6428849, compound

Product 1

HCID 208063351,5-Dimethylpiperazin-2-one

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1,5-dimethylpyrazin-2(1H)-one (5.7 g, 45.9 mmol) and platinum oxide (0.57 g) in ethyl acetate (100 mL) was stirred under an atmosphere of hydrogen (1 atm) at room temperature overnight. The product mixture was filtered through a pad of Celite, and concentrated under vacuum to provide 1,5-dimethyl-piperazin-2-one.

Workup

  1. filtrationThe product mixture was filtered through a pad of Celite
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-3fc24955cc784791a1dd1fc5b9340386
Source dataset
uspto-grants-2009_05
Patent number
US07538112B2

Reaction notes

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