Phenylboronic Acid → 2-Methoxy-N-quinolin-7-yl-1,1'-biphenyl-4-carboxamide

HRID 494262Notes

Reaction equation

HRID 494262 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[O:7])=[CH:4][C:3]=1[O:21][CH3:22].[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:22][O:21][C:3]1[CH:4]=[C:5]([C:6]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[O:7])[CH:19]=[CH:20][C:2]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 690426704-bromo-3-methoxy-N-quinolin-7-ylbenzamide

Product 1

HCID 576826982-Methoxy-N-quinolin-7-yl-1,1'-biphenyl-4-carboxamide

Procedure

Using the procedure outlined in Example 58, the title compound was prepared from 4-bromo-3-methoxy-N-quinolin-7-ylbenzamide (D69) (76 mg, 0.21 mmol) and phenylboronic acid (28 mg, 0.23 mmol) as a white solid. MS(ES): MH+ 355, M-H+ 353.

Sources & evidence

ORD record
ord-045557b01b2a467f93ec528345cefeca
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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