反应详情

To a solution of 7-aminoquinoline (D55) (338 mg, 0.26 mmol) in DCM (3 ml) was added 4-(2-methylpyrid-4-yl)-benzoic acid (D72) (62 mg, 0.29 mmol), 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide hydrochloride (74 mg, 0.39 mmol) and 4-dimethylaminopyridine (6 mg, 0.05 mmol) and the reaction stirred at room temperature until complete by tlc. The resultant precipitate was filtered off to give the title compound as an off-white solid. MS(ES): MH+ 340, M-H+ 338

1. filtrationThe resultant precipitate was filtered off