反应详情

A mixture of 1.2 g (4 mmol) 4-(5-methyl-3-phenyl-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid methyl ester and 1.3 g (31 mmol) LiOH.H2O in 40 mL THF, 5 mL methanol and 10 mL water was heated to reflux for 3 h. The mixture was concentrated, acidified and extracted with ethyl acetate. The combined organic extracts were dried with Na2SO4 and evaporated to yield 1.1 g (96%) of the title compound as light yellow solid. (m/e): 295.1 (M−; 100%).

1. temperaturewas heated
2. temperatureto reflux for 3 h
3. concentrationThe mixture was concentrated
4. extractionextracted with ethyl acetate
5. dry with materialThe combined organic extracts were dried with Na2SO4
6. customevaporated