反应详情

温度

0 °C

Sodium hydride (406 mg) was dissolved in dimethylformamide (20 mL) and the solution was cooled to 0° C. To this solution was added phenylmalonic acid diethyl ester (2.0 g), and the mixture was stirred at room temperature for 30 minutes. Bromoethyl benzyl ether (2.0 g) was further added thereto, stirred at 60° C. for 4 hours, and water was added thereto. The reaction mixture was concentrated, diluted with ethyl acetate, washed with water, dried over sodium sulfate and purified by column chromatography on silica gel with ethyl acetate:hexane=1:9 to give the title compound (1.2 g).

1. stirringstirred at 60° C. for 4 hours
2. concentrationThe reaction mixture was concentrated
3. additiondiluted with ethyl acetate
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. custompurified by column chromatography on silica gel with ethyl acetate