2-(2-Methyl-3-nitrophenyl)acetic acid → HCID 57683265, compound

HRID 494396Notes

Reaction equation

HRID 494396 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].[CH2:15]([O:17][C:18](=[O:34])[C:19]([CH2:31][CH2:32]O)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:16]>CN(C)C1C=CN=CC=1>[CH2:23]([O:22][C:20](=[O:21])[C:19]([CH2:31][CH2:32][O:13][C:12](=[O:14])[CH2:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[CH3:1])([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:18]([O:17][CH2:15][CH3:16])=[O:34])[CH3:24]

Participants

4

Reactant 2

HCID 135308972-(2-Methyl-3-nitrophenyl)acetic acidHCID 57683249HCID 57683249, compound

Product 1

HCID 57683265HCID 57683265, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

The 2-methyl-3-nitrophenylacetic acid (307 mg) obtained in Example 5c), 4-dimethylaminopyridine (217 mg) and the 2-(2-hydroxyethyl)-2-phenylmalonic acid diethyl ester (250 mg) obtained in Example 5e) were subjected to reactions similar to those in Example 1-3c) to give the title compound (366 mg).

Sources & evidence

ORD record
ord-d026ed1a4cdc49de8455c6bcd22cab1c
Source dataset
uspto-grants-2009_05
Patent number
US07538140B2

Reaction notes

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