Diethyl Malonate → Dimethyl 2-(2-isopentyl-5-methyl-2-phenylhexanoyl)malonate

HRID 494461Notes

Reaction equation

HRID 494461 reaction equation
[C:1]([O:9][CH2:10]C)(=[O:8])[CH2:2][C:3]([O:5][CH2:6]C)=[O:4].[CH2:12]([C:17]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])[C:18](Cl)=[O:19])[CH2:13][CH:14]([CH3:16])[CH3:15].C1(C(CCC)(CCC)C(Cl)=O)C=CC=CC=1>>[CH2:12]([C:17]([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)([CH2:21][CH2:22][CH:23]([CH3:24])[CH3:25])[C:18]([CH:2]([C:1]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4])=[O:19])[CH2:13][CH:14]([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 116873352-Phenyl-2-propylpentanoyl chlorideHCID 865980202-isopentyl-5-methyl-2-phenylhexanoyl Chloride

Product 1

HCID 69270654Dimethyl 2-(2-isopentyl-5-methyl-2-phenylhexanoyl)malonate

Procedure

The title compound was prepared following the procedure of Example 1E, substituting dimethyl malonate for diethyl malonate, and substituting the product of Example 6D for the product of Example 1D. 1H NMR (300 MHz, CDCl3): δ 7.32 (m, 5 H), 4.54 (s, 1 H), 3.56 (s, 6 H), 2.00 (m, 4 H), 1.49 (m, 2 H), 0.87 (m, 16 H).

Sources & evidence

ORD record
ord-899e710a521e460ca2b43c92637f89f4
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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