Hydrochloric Acid → HCID 136384866, compound

HRID 494571Notes

Reaction equation

HRID 494571 reaction equation
[CH:1]1([CH2:7][C:8]2([CH3:40])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([OH:18])=[C:10]([C:19]3[NH:24][C:23]4[CH:25]=[CH:26][C:27]([NH:29]C(=O)OC(C)(C)C)=[CH:28][C:22]=4[S:21](=[O:38])(=[O:37])[N:20]=3)[C:9]2=[O:39])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:41]>O1CCOCC1>[ClH:41].[NH2:29][C:27]1[CH:26]=[CH:25][C:23]2[NH:24][C:19]([C:10]3[C:9](=[O:39])[C:8]([CH2:7][CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)([CH3:40])[C:17]4[C:12]([C:11]=3[OH:18])=[CH:13][CH:14]=[CH:15][CH:16]=4)=[N:20][S:21](=[O:38])(=[O:37])[C:22]=2[CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136384565HCID 136384565, compound

Product 1

HCID 136384866HCID 136384866, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 41G (1.44, 2.56 mmol) in 4M hydrochloric acid in 1,4-dioxane (10 mL) was stirred at 25° C. for 1 hour. The solution was concentrated in vacuo and the residue was triturated in diethyl ether to give the title compound (1.17 g, 91%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.78 (m, 7H) 1.35 (m, 7H) 2.20 (m, 2H) 7.02 (m, 2H) 7.50 (m, 2H) 7.76 (m, 2H) 8.16 (m, 1H) 13.61 (m, 1H).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customthe residue was triturated in diethyl ether

Sources & evidence

ORD record
ord-ff6b685c47534041be96b666951089d6
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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