Tetrabutylammonium Fluoride → HCID 57682805, compound

HRID 494983Notes

Reaction equation

HRID 494983 reaction equation
C([Si]([O:8][CH2:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[C:13]([CH2:18][CH:19]2[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]2)=[CH:12][C:11]=1[N+:26]([O-:28])=[O:27])(C)C)(C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1.C(OCC)(=O)C>[CH3:24][C:21]1([CH3:25])[O:20][CH:19]([CH2:18][C:13]2[C:14]([O:16][CH3:17])=[CH:15][C:10]([CH2:9][OH:8])=[C:11]([N+:26]([O-:28])=[O:27])[CH:12]=2)[CH2:23][O:22]1

Participants

5

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 57682793HCID 57682793, compound

Product 1

HCID 57682805HCID 57682805, compoundYield 97.8%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

358 mg of t-butyl(4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-5-methoxy-2-nitrobenzyloxy)dimethylsilane was dissolved in 10 ml of tetrahydrofuran. While cooling on ice, 1 ml of a tetrahydrofuran solution containing 1.0 M tetrabutyl ammonium fluoride was added to the reaction solution, and the obtained mixture was then stirred at room temperature for 3 hours. Thereafter, the reaction solution was diluted with ethyl acetate and then washed with a saturated sodium chloride aqueous solution. The organic layer was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate), so as to obtain 253 mg of (4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-5-methoxy-2-nitrophenyl)methanol.

Workup

  1. additionwas added to the reaction solution
  2. washwashed with a saturated sodium chloride aqueous solution
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated under a reduced pressure
  5. customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate)

Sources & evidence

ORD record
ord-07eaf91dd0e649f98492ecabbd0eca9c
Source dataset
uspto-grants-2009_05
Patent number
US07538123B2

Reaction notes

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