反应详情

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (100 mg) was dissolved in a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml). Thereafter, a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml) containing L-(+)-tartaric acid (31 mg) was added to the reaction solution at room temperature. The deposited solid was collected by filtration, and the obtained product was then washed with diethyl ether, so as to obtain the subject compound (110 mg).

1. additionwas added to the reaction solution at room temperature
2. filtrationThe deposited solid was collected by filtration
3. washthe obtained product was then washed with diethyl ether