反应详情

To a flask were added 1.0 g di-(2-picolyl)amine, 0.85 g of pulverized potassium hydroxide and 15 ml of N,N-dimethylformamide. After stirring for 1 hour under nitrogen, the mixture was cooled to 5 C and 1.7 g of 1-iodopropane were added. The mixture was heated to 35 C and stirred for 16 hours. After quenching with 30 ml water, the product was extracted with ethyl acetate and washed twice with water. Following removal of solvent, the product was purified by silica gel chromatography using ethyl acetate to give 0.65 g of a yellow oil.

1. additionwere added
2. temperatureThe mixture was heated to 35 C
3. stirringstirred for 16 hours
4. customAfter quenching with 30 ml water
5. extractionthe product was extracted with ethyl acetate
6. washwashed twice with water
7. customremoval of solvent
8. customthe product was purified by silica gel chromatography