Formaldehyde → HCID 11314307, compound

HRID 495280Notes

Reaction equation

HRID 495280 reaction equation
[OH:1][C:2]1[C:3]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:5]=[C:6]([OH:8])[CH:7]=1.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.[CH2:26]=O>CC(O)C>[OH:8][C:6]1[C:5]([CH2:26][N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[C:4]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:3]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:2]([OH:1])[CH:7]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 11230647HCID 11230647, compound

Product 1

HCID 11314307HCID 11314307, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Compound 1 (0.19 g, 0.74 mmol) obtained in Example 1 was dissolved in 2-propanol (3.0 mL), and morpholine (0.065 mL, 0.75 mmol) and aqueous 37% formalin solution (0.063 mL, 0.78 mmol) were added thereto and stirred at room temperature for 4 hours. The reaction solution was concentrated under reduced pressure, and then purified through preparative thin-layer chromatography (methanol/chloroform=1/9) to obtain Compound 14 (0.091 g, 35%) as a colorless oily substance.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. custompurified through preparative thin-layer chromatography (methanol/chloroform=1/9)

Sources & evidence

ORD record
ord-1b2301b07acb41b096490b0341de3221
Source dataset
uspto-grants-2009_05
Patent number
US07538241B2

Reaction notes

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