Hydrochloric Acid → HCID 23147049, compound

HRID 495283Notes

Reaction equation

HRID 495283 reaction equation
[Br:1][C:2]1[C:7]([O:8]COC)=[CH:6][C:5]([O:12]COC)=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:3]=1[CH2:22][CH2:23][CH2:24][O:25][CH3:26].Cl>C(O)C>[Br:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([OH:12])=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:3]=1[CH2:22][CH2:23][CH2:24][O:25][CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23147610HCID 23147610, compound

Product 1

HCID 23147049HCID 23147049, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

In the same manner as in the step 2 in Example 25, 4-bromo-1,5-bis(methoxymethoxy)-3-(3-methoxypropyl)-2-phenylbenzene (37.2 mg, 0.0875 mmol) was dissolved in ethanol (4 mL), and concentrated hydrochloric acid (0.1 mL) was added thereto and stirred at 60° C. for 1.1 hours. The reaction liquid was concentrated under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (chloroform/methanol=20/1) to obtain Compound 97 (28.7 mg, 97%).

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. customthe resulting residue was purified
  4. customthrough partitioning thin-layer chromatography (chloroform/methanol=20/1)

Sources & evidence

ORD record
ord-056a61fed9f94964b109d53370db0d30
Source dataset
uspto-grants-2009_05
Patent number
US07538241B2

Reaction notes

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