反应详情

Methyl 2-ethyl-3,5-dihydroxyphenylacetate (1.70 g, 8.09 mmol) was dissolved in acetone (20 mL), and potassium carbonate (6.43 g, 46.5 mmol) and benzyl bromide (4.00 mL, 33.6 mmol) were added thereto ad stirred at room temperature for 6 hours. Water was added to the reaction mixture, and extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, then dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was purified through silica gel column chromatography (n-hexane/ethyl acetate=20/1 to 9/1) to obtain methyl 3,5-bis(benzyloxy)-2-ethylphenylacetate (2.08 g, 66%).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with aqueous saturated sodium chloride solution
3. dry with materialdried over anhydrous sodium sulfate
4. customthe solvent was evaporated away under reduced pressure
5. customThe resulting residue was purified through silica gel column chromatography (n-hexane/ethyl acetate=20/1 to 9/1)