反应详情

In the same manner as in the step 1 in Example 316, methyl 3-{2-[3,5-bis(benzyloxy)-2-ethyl-6-phenylphenyl]ethylamino}-3-hydroxypropionate was obtained from 2-[3,5-bis(benzyloxy)-2-ethyl-6-phenylphenyl]ethanal (280 mg, 0.64 mmol) obtained in the step 1 in Example 218, using acetic acid (0.6 mL), methyl 3-amino-3-hydroxypropionate (150 mg, 0.97 mmol), sodium triacetoxyborohydride (270 mg, 1.3 mmol) and 1,2-dichloroethane (6.0 mL). Then, in the same manner as in the step 2 in Example 315, methyl 3-{2-[3,5-bis(benzyloxy)-2-ethyl-6-phenylphenyl]ethyl}-2-oxo-1,3-oxazolidine-4-carboxylate (230 mg, 63%) was obtained from methyl 3-{2-[3,5-bis(benzyloxy)-2-ethyl-6-phenylphenyl]ethylamino}-3-hydroxypropionate obtained in the above.

1. customobtained in the step 1 in Example 218