Hydrogen Bromide → 100949-04-0

Temperature

0 °C

To a mixture of 4-methoxyindole (1.26 g, 8.57 mmol), powdered potassium hydroxide (10.05 g, 0.179 mol) and dry dimethylformamide (20 mL) at 15° C. under argon was added, portionwise over 0.2 h, hydroxylamine-O-sulfonic acid. Internal temperature was kept ≦30° C. by external ice bath cooling. The mixture was stirred at 20° C. for 4 h, then was extracted with toluene (4×50 mL). The combined extracts were washed with water (4×50 mL) and brine (50 mL), then dried (Na2SO4) and evaporated in vacuo to give an oil. Chromatography of the residue on silica with 5-50% ether in hexane gradient elution gave 1-amino-4-methoxyindole (0.79 g, 56%). A mixture of 1-amino-4-methoxyindole (0.78 g, 4.8 mmol), nitrobenzene (3.4 g, 27.8 mmol), and methanolic HCl (3% w/w, 180 mL) was heated at reflux for 76 h, then cooled and partitioned between 10% aqueous NaOH (50 mL) and dichloromethane (3×30 mL). The combined organic extracts were dried (Na2SO4) and evaporated in vacuo to give an oil which was purified by chromatography on silica with 5-100% ether in hexane gradient elution. The resulting 5-methoxycinnoline (0.56 g, 3.5 mmol) was mixed with 48% aqueous HBr (35 mL) and the resulting solution heated at reflux for 18 h. The mixture was cooled, then evaporated in vacuo, and the residue dissolved in water (10 mL). Aqueous ammonia (d=0.880) was added until pH 6 was obtained, and the resulting mixture cooled to 0° C. The precipitated solid was collected by filtration and purified by charcoal-methanol treatment to give the title compound (0.37 g, 53%) as a yellow solid.

1. temperaturewas heated
2. temperatureat reflux for 76 h
3. temperaturecooled
4. custompartitioned between 10% aqueous NaOH (50 mL) and dichloromethane (3×30 mL)
5. dry with materialThe combined organic extracts were dried (Na2SO4)
6. customevaporated in vacuo
7. customto give an oil which
8. customwas purified by chromatography on silica with 5-100% ether in hexane gradient elution
9. temperaturethe resulting solution heated
10. temperatureat reflux for 18 h
11. temperatureThe mixture was cooled
12. customevaporated in vacuo
13. dissolutionthe residue dissolved in water (10 mL)
14. additionAqueous ammonia (d=0.880) was added until pH 6
15. customwas obtained
16. filtrationThe precipitated solid was collected by filtration
17. custompurified by charcoal-methanol treatment

ORD record

ord-5f47137dd805497c9191fe834d820e14

Source dataset

uspto-grants-2005_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06939871B2