反应详情

To a solution of 5-(2-amino-4,5-dimethoxy-phenyl)-pentanoic acid ethyl ester (Example 122, Step B) (0.1 g, 0.35 mmol) in THF (3 mL) was added NaOH (2 M, aqueous) (3 mL) and the mixture was stirred vigorously at RT for 12 h. The reaction was neutralized by the slow addition of HCl (2 N, aqueous) followed by removal of the THF under reduced pressure. The aqueous mixture was extracted with CH2Cl2 (3×10 mL) and the organic layers were combined, washed with brine, dried with MgSO4, and filtered. Concentration under reduced pressure afforded the title compound as a brown solid that was carried on without purification.

1. customfollowed by removal of the THF under reduced pressure
2. extractionThe aqueous mixture was extracted with CH2Cl2 (3×10 mL)
3. washwashed with brine
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. concentrationConcentration under reduced pressure