反应详情

3-Bromoaniline (2.63 g, 15.3 mmol) was dissolved in ethyl acetate (100 ml) and 1N dry hydrogen chloride in diethyl ether (15.3 ml) was added and the solvents were removed in vacuo. The residue was stripped twice with toluene and the residue was suspended in toluene (30 ml). Diphosgene (6.1 ml) was added and the mixture was refluxed for 1.5 hour. After cooling, the solution was concentrated in vacuo to afford 2.63 g (87%) 3-bromophenyliso-cyanate.

1. customthe solvents were removed in vacuo
2. additionDiphosgene (6.1 ml) was added
3. temperaturethe mixture was refluxed for 1.5 hour
4. temperatureAfter cooling
5. concentrationthe solution was concentrated in vacuo